In the presence of the α-Syn oligomer, the target triggered cycle I strand displacement amplification and achieved the conversion of the α-Syn oligomer to a massive output of false-target DNA (FT). The signal indicator, dopamine/4-mercaptophenyl boronic acid/WSe 2 (DA/MBA/WSe 2), was generated with the recognition of boron–diol. Due to the synergistic effect of AuNPs/GDY and WSe 2, this detection strategy provides a high signal-to-noise ratio and good performance. The synergy effect between the WSe 2 nanoflower and graphdiyne (GDY) can reduce the photoinduced electron–hole recombination and expedite the spatial charge separation. A tungsten selenide (WSe 2) nanoflower was first produced with a one-pot solvothermal method and employed as a signal amplification element and the modified substrate of the nanoprobe. We developed a method for photoelectrochemical (PEC) sensing based on a AuNPs/graphdiyne, as a low background signal composite material, modified electrode coupled with a nanoprobe (probe DNA/DA/MBA/WSe 2) for sensitive α-synuclein (α-Syn) detection.
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